The Interaction between Systemic Lupus Erythematosus and Cardiovascular Disease: Systematic Review

Hyder Osman Mirghani; Nasser Mansour M Alatawi; Mazin Turki Alenzi; Ibrahim Ahmed I Alghamdi; Waad Salmah J Alatwai; Ghadi Saleh M Alqarni; Razan Imad M Bahkali; Nada  Suliaman E Alatawi; Arwa Fraih N Alenezi; Rand Fahad M Albaridi; Moaeed Turki M Alhamrani; Salman  Ali A Alshamrani; Alaa Mansour F Althobiti

doi:10.54293/smhj.v4i3.115

Authors

Hyder Osman Mirghani 1- Prof. of Internal Medicine and Endocrine, Department of Internal Medicine, Faculty of Medicine, University of Tabuk, KSA. https://orcid.org/0000-0002-5817-6194
Nasser Mansour M Alatawi Medical Student, Faculty of Medicine, University of Tabuk, Tabuk, KSA.
Mazin Turki Alenzi Medical Student, Faculty of Medicine, University of Tabuk, Tabuk, KSA.
Ibrahim Ahmed I Alghamdi Medical Student, Faculty of Medicine, king Khalid University, Abha, KSA.
Waad Salmah J Alatwai Medical Student, Faculty of Medicine, University of Tabuk, Tabuk, KSA. https://orcid.org/0009-0009-4070-4911
Ghadi Saleh M Alqarni Pharmacist at Alnahdi company,Tabuk, KSA.
Razan Imad M Bahkali Medical student, College of Medicine, Almaarefa University, Riyadh, KSA.
Nada Suliaman E Alatawi Medical Student, Faculty of Medicine, University of Tabuk, Tabuk, KSA.
Arwa Fraih N Alenezi Medical Student, Faculty of Medicine, University of Tabuk, Tabuk, KSA.
Rand Fahad M Albaridi Medical Student, Faculty of Medicine, University of Tabuk, Tabuk, KSA. https://orcid.org/0009-0001-4972-307X
Moaeed Turki M Alhamrani Medical Student, Faculty of Medicine, king Khalid University, Abha , KSA.
Salman Ali A Alshamrani Medical Student, Faculty of Medicine, University of Tabuk, Tabuk, KSA.
Alaa Mansour F Althobiti Medical Student, Faculty of Medicine, University of Tabuk, Tabuk, KSA.

DOI:

https://doi.org/10.54293/smhj.v4i3.115

Keywords:

Keywords: Systemic Lupus Erythematous, Cardiovascular Diseases, SLE, Myocardial, Lupus, Risk Factors.

Abstract

Patients diagnosed with systemic lupus erythematosus (SLE) face a much greater risk of morbidity and mortality from cardiovascular disease (CVD) when compared to the overall population. Despite numerous case reports and literature reviews delving into this connection, there are only a handful of systematic reviews that have specifically concentrated on this link. As a result, the objective of this systematic review is to assess the depth of the relationship between SLE and cardiovascular diseases. An extensive search was conducted primarily using PubMed and following PRISMA criteria. The search targeted English-language studies investigating the link between SLE and cardiovascular diseases. Clear inclusion and exclusion criteria were set to guarantee the quality and relevance of the evaluated research. The research encompassed a broad spectrum of studies from various global regions, with no particular emphasis on any specific gender or age. An evident trend revealed a significant proportion of SLE patients experiencing cardiovascular conditions. According to the findings of our investigation, in general, it was discovered that patients with SLE have a greater chance of developing CVD. It is essential to conduct additional research on the connection between identifiable SLE-specific risk factors that can be modified and the likelihood of developing CVD in order to bolster the creation of preventative and treatment measures.