Does Cabergoline Prevent Ovarian Hyperstimulation Syndrome? Systematic Review

Authors

  • Yousef Mohammed Elamin Obstetric and Gynecology Consultant, Abha maternity and children hospital MOH, Abha, KSA.
  • Ahdab Faisal Nono Obstetric and Gynecology Senior Registrar, Saudi German Hospital, Jeddah,KSA.
  • Arwa Abdulrahman Abdulaziz Saber Obstetric and Gynecology Resident, National Guard Hospital - Jeddah,KSA. https://orcid.org/0000-0003-1309-4301
  • Reham Lafi Ahmed Alghamdi Obstetrics and Gynecology Resident, Khobar, King Fahad University Hospital,KSA.
  • Baraah Sohaib Anwar Abdulrashid Obstetric and Gynecology Resident, Jeddah, Dr. Sulaiman Fakeeh Hospital,KSA.
  • Kholoud Abdullah Alotebi Obstetric and Gynecology Senior Registrar, King Faisal Medical Complex,KSA.
  • Jumanah Fahad Mohamed Etaiwi Obstetric and Gynecology Resident, Riyadh, Dr. Sulaiman AlHabib Ar Rayan Hospital,KSA. https://orcid.org/0000-0001-6573-8979
  • Badriah Jariad Moqbel Alshammri Obstetric and Gynecology Resident, King Salman Armed Forces Hospital in Tabuk,KSA.
  • Roaa Abdullah Buhligah Obstetric and Gynecology Resident, Al-Ahsaa Maternity and Children’s Hospital,KSA. https://orcid.org/0009-0007-3482-4883
  • Rawan Sultan Al Hufayyn Obstetric and Gynecology Resident, Maternity and Children Hospital - Najran, KSA
  • Hajar Rida Mohammad Almoqbel Obstetrics and Gynecology Resident, AHSA Maternity and Children Hospital (MOH),KSA.
  • Rawan Ahmed Ibrahim Haimed Obstetric and Gynecology Resident, Maternity Hospital in King Saud Medical City in Riyadh,KSA.

DOI:

https://doi.org/10.54293/smhj.v5i2.149

Keywords:

Cabergoline; OHSS prevention; Calcium gluconate; Alternative treatments; Reproductive medicine; Systematic review.

Abstract

 

The main objective of this study is to evaluate the available evidence on the efficacy of cabergoline in the prevention of ovarian hyperstimulation syndrome (OHSS) in patients undergoing fertility treatments. A comprehensive search of four databases identified 712 relevant publications. After duplicate removal using Rayyan QCRI and relevance screening, the search identified 346 publications, of which 101 full-text articles were reviewed, six of which met the eligibility criteria for the evidence synthesis. We included six studies with a total of 919 women: 440 in the cabergoline group and 479 in the control group. The prevalence of OHSS in the cabergoline group ranged from 8.3% to 65.6%, for an overall prevalence of 34.8%. In the control group, the incidence of OHSS ranged from 10.59% to 77.8%, for an overall prevalence of 32.9%. Cabergoline is effective in reducing moderate to severe OHSS, especially compared to placebo, making it a suitable choice for high-risk women. However, it is less effective than calcium gluconate in preventing mild OHSS, and the incidence of mild cases is higher. Alternative treatments, including quinagolide, diosmin, and calcium injections, have shown superior efficacy in preventing OHSS. In conclusion, cabergoline effectively reduces moderate to severe OHSS, especially compared to placebo, but is less effective than calcium gluconate in mild cases. Alternative treatments, such as diosmin, diosmin, and calcium injections, may offer better outcomes in specific cases. Tailoring treatment based on the patient's risk factors is essential.

 

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Published

2025-05-17

How to Cite

1.
Elamin YM, Nono AF, Saber AAA, Alghamdi RLA, Abdulrashid BSA, Alotebi KA, Etaiwi JFM, Badriah Jariad Moqbel Alshammri, Buhligah RA, Al Hufayyn RS, Almoqbel HRM, Haimed RAI. Does Cabergoline Prevent Ovarian Hyperstimulation Syndrome? Systematic Review. SMHJ [Internet]. 2025 May 17 [cited 2025 Jun. 1];5(2):121-9. Available from: https://smh-j.com/smhj/article/view/149

Issue

Section

Review Article