Catheter-Based Ultrasound Renal Denervation in Patients with Resistant Hypertension: A Systematic Review

Siraj Fahad Wally; Abdulaziz  Ahmed M Albalawi; Shaykhah  Salman A Alderaan; Rammy  Abdullah A Asseiri; Rayan Ahmed I Alharbi; Faisal Mohammed Oudah Alamrani; Shatha  Oliyan E Albalawi; Ali  Fahad B Alsharif; Rawan  Hussain Q Albalawi; Lubna  Ibrahim H Alomari; Ghadeer  Saud O Almarwani; Hala  Ali D Alshaman

doi:10.54293/smhj.v3i3.83

Authors

Siraj Fahad Wally Assistant professor, Radiology department, Tabuk University, KSA.
Abdulaziz Ahmed M Albalawi Medical intern, Faculty of Medicine in Tabuk University, Tabuk, KSA. https://orcid.org/0009-0005-9231-0085
Shaykhah Salman A Alderaan Medical Intern, Faculty of Medicine in Tabuk University, Tabuk, KSA. https://orcid.org/0000-0001-7801-1795
Rammy Abdullah A Asseiri Student, Faculty of Medicine, Tabuk University, Tabuk, KSA. https://orcid.org/0009-0009-2346-2033
Rayan Ahmed I Alharbi Student, Faculty of Medicine in Tabuk University, Tabuk, KSA.
Faisal Mohammed Oudah Alamrani Student, Faculty of Medicine in Tabuk University, Tabuk, KSA.
Shatha Oliyan E Albalawi Student, Faculty of Medicine, Tabuk University, Tabuk, KSA.
Ali Fahad B Alsharif Medical intern, Faculty of Medicine, Tabuk University, Tabuk, KSA. https://orcid.org/0009-0001-4568-3226
Rawan Hussain Q Albalawi Student, Faculty of Medicine, Tabuk University, Tabuk, KSA.
Lubna Ibrahim H Alomari Medical Intern, Faculty of Medicine, Tabuk University, Tabuk, KSA. https://orcid.org/0009-0001-7328-3422
Ghadeer Saud O Almarwani Student, Faculty of Medicine, Tabuk University, Tabuk, KSA. https://orcid.org/0009-0008-5626-1548
Hala Ali D Alshaman Student, Faculty of Medicine, Tabuk University, Tabuk, KSA.

DOI:

https://doi.org/10.54293/smhj.v3i3.83

Keywords:

Renal Denervation, Catheter, Ultrasound, Blood Pressure, Ambulatory Blood Pressure, Resistant Hypertension

Abstract

Background: The maintenance and development of hypertension are fundamentally dependent on renal sympathetic hyperactivity. Through regulation of the renal sympathetic nerves, catheter-based renal sympathetic denervation has been demonstrated to dramatically lower blood pressure (BP) in patients with resistant hypertension (systolic blood pressure 160 mm Hg on three or more antihypertensive medicines, including a diuretic). This study assessed a catheter-based ultrasound device of the next generation intended to maximize nerve coverage using circumferential ultrasound energy. This study's objective is to describe the results of renal denervation (RDN) in patients with resistant hypertension using a catheter-based ultrasonography device to measure blood pressure and safety. A potential new non-pharmacological therapy for resistant hypertension is renal denervation.

Method: PubMed, Web of Science, Science Direct, Cochrane Library, and Google Scholar were thoroughly searched for relevant material. Throughout this meticulous process, the Rayyan QRCI was used.

Results: our review included 10 studies with parameters including the period of study, age range of patients, office blood pressure, ambulatory blood pressure and the used approach. Clinical studies are required to determine whether this method is effective in treating this resistant hypertension.

Conclusion: In individuals with resistant hypertension, catheter-based ultrasound renal denervation significantly and persistently lowers blood pressure and has no negative effects on renal function or renal artery anatomy.